In the agriculture industry, pesticides are not something unfamiliar to be recognized by the internal parties. Pesticides are materials used to control, reject, or eradicate plant pests. Since hundreds of years ago pesticides have been used by humans in the agriculture industry to prevent its plant from the pests, however, today the type of pesticides is more vary than it used to. Types of pesticides depend on their targets such as insecticides to kill insects, fungicides for fungi, herbicides for weeds, and bactericidal bacteria. Pesticides are proven to improve agricultural yields.

       As an agrarian country that increases its development through agro technology sector, Indonesia's agriculture sector cannot be separated from the use of pesticides. In its old era, Indonesia launched a policy on food intensification program through a national program called "BIMAS", then pesticides have been included as a technology package that farmers must use to improve agricultural products. Even then, the government generously subsidized the procurement of pesticides by 80 percent, so the price of pesticides on the market becomes very cheap. Not only that, the type of pesticide used and the schedule of its usage is regulated by the government. The recommended type of pesticide is generally a broad-spectrum killer pesticide with the capability of killing most of the organisms it produces, including useful organisms such as natural enemies of pests and other non-target organisms that coexist with plant-disturbing organisms.

        In the beginning, agricultural output produced in Indonesia is very satisfactory because of the increasing number of the product produced, but everything changed when the evaluation shows an unconscious loss that previously unexpected. Some of the disadvantages arising from the control of plant-disturbing organisms that rely solely on pesticides, among others, cause resistance to pests, encouraging resurgence, killing of natural enemies and non-target organisms, and causing secondary pest population explosions.

       In today's modern era, the use of pesticides in Indonesia is still classified in massive level. In the middle of this year, one of the areas in Indonesia named Brebes was titled as the city with the biggest pesticide usage in Southeast-Asia, that title is something that we should not be proud of. This happens because the farmers in the area want an increase in agricultural output regardless of the negative impact that it may cause. They are on average using a type of Chlorpyrifos pesticide (insecticide organosphate group) and Mancozeb (fungicide carbamate group). Both of these substances are known to be thought to cause the growth of the thyroid gland to increase.

          At a glance, the use of pesticides seems to provide good benefits for the agricultural industry. The reasons that encourage farmers to use pesticides are non-other than because pesticides are easy to be applied, applicable in various times and places, can have immediate impacts, can be applied in large areas for a short time, and are easy to obtain and provide short-term economic benefits.

        However, the negative impacts of pesticide outweigh its benefits. Negative impacts caused by the usage of pesticides are including pollution of river, pond, swamp / lake and aquatic ecosystems, pollution of horticultural vegetable ecosystems, pollution of pest populations, pathogens and natural enemies, global warming, and pollution to human health. Pesticides poison humans not only when the pesticide is used, but also when it is prepared, or after spraying. Accidents caused by pesticides to humans often occur, especially experienced by people who directly do the spraying activity.

        In conclusion, pesticides are not only had positive impacts on improving agricultural products, but also have numerous negative impacts for the surrounding environment. We suggest an establishment of directive and terms to use the pesticides for the users in terms of dosing, time of application, and safe work, these activities are expected to reduce the inefficiency of pesticide usage in the environment and reduce the smallest possible pollution. In the future, it is hoped that the use of pesticides will be reduced and supported by the upcoming new findings that are more effective in overcoming the interference of this intruder, we hope that pesticides are expected to be the last solution for the industry to solve the pests issue. In line with this objective, the government of the Republic of Indonesia since 1986 has issued policies and measures that can limit and reduce the usage of pesticides. Moreover, through its Presidential Instruction no. 3 in 1986, Indonesia has conducted the program of handling plant pest organisms by applying the principle of integrated pest management (IPM) as its national program, which is an effort to anticipate the adverse effects of pesticide use.