Climate change is global phenomenon starting from environment and affecting environmental parameters. Climate change induced(about 88%) by anthropogenic emission  of green house gases  as water vapor, CO₂, CH₄, N₂O, and CFCs. Nepal?s agri based economy is threaten by affecting human heath, resources etc. Temperature recorded rates of warming is greater in Himalaya (0.04⁰c to 0.09⁰C) than global average(0.03 to 0.07⁰C) thus Himalayan region has played a special role in understanding climate change mainly through study of glaciers.  Climate change has affect the public health with disease as cardio-respiratory, injuries, psychological stress & malnutrition, vector borne disease and water borne diseases which affect the Nepalese agriculture labor. Climate change impact on agriculture has decrease in productivity in certain area whereas increase in other. Rainfall pattern shifting in onset and retreat of rainfall not only affects the rainfed farming in Nepal also it bring drought and floods affecting moisture availability, erosion and inundation of standing crops. Climate change has shown initial positive effect (increased temp and co₂ content) but shown negative impacts in the long run. Positive: Enhanced photosynthesis, water use efficiency, soil microbial activities. Negative: Productivity of crop, nutritional value, soil fertility, microbial activities, desertification, shifting of pest and disease in higher elevation direct and indirect impact in economy, effects on livestock, extinction of the local gene pool etc results in damaging effect in agriculture and Nepal?s agriculture based economy. It?s time for work to done from grass root level but initiation from higher authorities to save the environment and country.