As a student of Veterinary science and medicine, i feel it is my responsibility to share about zoonotic diseases so today i want to discuss about Tuberculosis. I have prepared this report from various websites and slide share. I mentioned the link below. I hope you will learn good enough about TB. 

Tuberculosis in Elephants and Humans
TB infects over 2 billion people or one third of the world’s population and it is also estimated that 1.5 to 2 million people die from tuberculosis each year. A total of 95% of cases occur in humans in developing countries. Worldwide it is said to be the leading cause of death by infectious disease.
Bovine tuberculosis (BTB) is the zoonotic disease transmitted from animal to human and makes a significant economic impact due to high cost of eradication programs and has serious consequences for movements of animals and their products, biodiversity, public health and significant economic effect
M. tuberculosis is the main cause of TB in Elephants, Rhinoceroses, Tapirs, and in some exotic bovine spp. In Larger land mammals (Ungulates), TB is mostly caused by M. bovis. In zoo primates TB is due to M. tuberculosis and M. bovis. A number of cases reported among wild animals worldwide.
Bovine tuberculosis is a chronic infectious zoonotic disease of domestic animals and humans. It is characterized by formation of granulomas in tissue especially the lungs, lymph nodes, liver, intestines and the kidneys. Mycobacterium bovis is the main etiological agent of BTB (Bovine tuberculosis) which is an acid fast staining bacterium due to waxy substance (mycolic acid) present in its bacterial cell wall. The bacteria can be transmitted by both aerogenous and enterogenous routes.
The first zoo elephant reportedly affected by TB was an Indian elephant that died at the London Zoo in 1875. Additional cases appeared in the literature in the early 20th Century. The first case of mycobacterium infection in an African elephant was reported in the 1960s.

Sources of Infection and Ways of Transmission
Bovine Tuberculosis can be transmitted in various ways. For instance in air that is exhaled; sputum and urine, feces as well as pus the bacteria can spread. Either direct contact or contact with infected animal excreta, aerosol inhalation can spread the disease that depends on the involvement of the species.

 
Clinical signs in elephants
As in humans, TB in elephants – which get infected aerogenically – can be a chronic, debilitating disease. Signs may include weakness, weight loss, exercise intolerance and coughing. Elephants may not show signs until the disease is quite advanced. Even in the absence of clinical signs, infected elephants can shed TB bacteria and infect others.
The current method used to diagnose TB in elephants is to culture samples obtained by a trunk wash procedure, similar to obtaining a sputum sample in humans. Sterile saline is placed in the trunk, the trunk is elevated, and the elephant is instructed to forcibly exhale into a collection device. Barring cross-contamination or laboratory error, a positive culture is an accurate indication of TB disease, but false-negatives do occur. The trunk-wash sample may be from the end of the trunk instead of from deeper in the respiratory tract as intended. Because elephants use their trunks for many purposes including eating and dust bathing, contamination of the sample is common, leading sometimes to delay or indecisive results.

Treatment
The main or “first line” drugs are isoniazid (INH), rifampin (RIF), ethambutol (ETH), and pyrazinamide (PZA). PZA is not effective against M. bovis and can only be used if the causative agent is M.tb. A precise (scale) weight is essential to determine accurate drug doses. Isoniazid and PZA can be given orally or rectally; rifampin and ethambutol must be given orally. The duration of the treatment is, generally, one year – longer than in humans while still being experimental.
Recommendations
It is important that calves being reared as herd replacements be fed on tuberculosis-free milk, either from known free animals or pasteurized.
- Vaccination against tuberculosis should be supplied for humans and animals as it is zoonotic disease
- Bio-security measures should be followed on herd/farm which helps in decreasing or reducing the interaction between domestic animals and wildlife animals
- Protective cloth should be worn during handling of the diseased animal and infected carcasses.
- Carcasses of infected animals should be buried at least four feet under the ground.
- The animal which is import from other state or country should be strictly quarantine
- Pasteurization of milk of before consumption.
- Strict meat inspection should be carried out officially by trained personal
- Treatment of infected animals is not economically feasible because of the high cost, lengthy time and the larger goal of eliminating the disease, so the infected animal should be tested and culled.
- Farm attendants should be checked as they may provide a source of infection.
- Training of personnel at all levels of control programmes and the urgent need for further research on the diagnosis and control, immunological, epidemiological and socioeconomic aspects of the disease.
- Educational and technical assistance should be provided by developed countries to promote control of tuberculosis.
Source
https://www.slideshare.net/singh_br1762/zoonotic-tuberculosis-in-elephanths
https://www.healio.com/infectious-disease/zoonotic-infections/news/print/infectious-disease-news/%7B193d8ef8-75be-4476-a39c-92b22d0b10d8%7D/tuberculosis-in-elephants-a-reverse-zoonosis?fbclid=IwAR1QUmU7nU1M0uRIUZvI4WAsKsFeb5HTFzvfWoCfBV_PUB-bMVDsxB8XBko
https://www.scirp.org/journal/PaperInformation.aspx?PaperID=69091